Chained activation of the motor system during language understanding

Two experiments were carried out to investigate whether and how one important characteristic of the motor system, that is its goal-directed organization in motor chains, is reflected in language processing. This possibility stems from the embodied theory of language, according to which the linguistic system re-uses the structures of the motor system. The participants were presented with nouns of common tools preceded by a pair of verbs expressing grasping or observational motor chains (i.e., grasp-to-move, grasp-to-use, look-at-to-grasp, and look-at-to-stare). They decided whether the tool mentioned in the sentence was the same as that displayed in a picture presented shortly after. A primacy of the grasp-to-use motor chain over the other motor chains in priming the participants' performance was observed in both the experiments. More interestingly, we found that the motor information evoked by the noun was modulated by the specific motor-chain expressed by the preceding verbs. Specifically, with the grasping chain aimed at using the tool, the functional motor information prevailed over the volumetric information, and vice versa with the grasping chain aimed at moving the tool (Experiment 2). Instead, the functional and volumetric information were balanced for those motor chains that comprise at least an observational act (Experiment 1). Overall our results are in keeping with the embodied theory of language and suggest that understanding sentences expressing an action directed toward a tool drives a chained activation of the motor system

Multiple stellar populations in Galactic globular clusters: observational evidence

An increasing number of both photometric and spectroscopic observations over the last years have shown the existence of distinct sub-populations in many Galactic globular clusters and shattered the paradigm of globulars hosting single, simple stellar populations. These multiple populations manifest themselves in a split of different evolutionary sequences in the cluster color-magnitude diagrams and in star-to-star abundance variations. In this paper we will summarize the observational scenario.Comment: 6 pages, 3 figures, Proceedings SF2A 201

Passenger car equivalent for heavy vehicles crossing turbo-roundabouts

Turbo-roundabouts represent an innovative scheme of modern roundabouts which provides a spiraling traffic flow and requires drivers to choose their direction before entering the intersection, since raised lane separators mark the lanes on the ring. The configuration of the turbo-roundabout makes that patterns of conflict at entries with one and two conflicting traffic streams can coexist. This paper presents research efforts aimed at measuring quantitatively the effect of heavy vehicles on operational conditions of a turbo-roundabout. The study starts from the initial belief that the greatest constraints to the vehicular trajectories imposed by the turbo-roundabout necessarily imply that the impact of heavy vehicles on the quality of traffic flow is more unfavorable than on other modern roundabouts. Microsimulation revealed as a useful tool when the variation of the traffic quality in turbo-roundabouts should be evaluated in presence of mixed fleets, each having different percentages of heavy vehicles; indeed, it allowed to isolate traffic conditions difficult to observe on field and replicate them to have a number of data as much as possible numerous. Entry capacity values for each entry lane of the turbo-roundabout were obtained by microsimulation, varying the percentage of heavy vehicles for entering flows. Nonlinear regression analysis of simulation data allowed to derive the behavioral parameters for heterogeneous populations of users and, ultimately, composed exclusively of heavy vehicles. The capacity functions thus obtained allowed us to determine how the passenger car equivalent (PCE) varies with the percentage of heavy vehicles and circulating flows for each entry lane of the turbo-roundabout. The results of this study indicate that there is a need to distinguish the impact of heavy vehicles when analyzing the capacity of a turbo-roundabout. When the traffic stream contains a significant number of heavy vehicles, a larger PCE effect would be expected. This effect should be accounted for in the estimation of the turbo-roundabout capacity. Lastly it should be emphasized that an important aspect of the research consists in having identified a methodology for assessing the impact of heavy vehicles on the quality of traffic flow, that can be applied to different patterns of intersection

The Formation of Globular Clusters as a Case of Overcooling

Driven by recent observational findings, we select massive interactive binaries as the most suitable among the existing candidates for producing the chemical patterns typical of multiple populations of Galactic globular clusters. Still, to avoid supernova contamination we are further driven to endorse the notion that above a critical mass stars fail to produce supernova events, but rather eventually sink into black holes without ejecting much energy and heavy metals. This assumption has the attractive implication of suppressing star formation feedback for some 5--10 million years, in practice leading to runaway star formation, analog to {\it overcooling} that in absence of feedback would have turned most baryons into stars in the early Universe. Under such conditions, multiple episodes of stars formation, incorporating binary star ejecta from previous episodes, appear to be unavoidable, thus accounting for the ubiquity of the multiple population phenomenon in globular clusters.Comment: 7 pages. Submitted December 13, 2021, in original form, accepter April 2, 2022. To appear on MNRA

Sequential development of large B cell lymphoma in a patient with peripheral T-cell lymphoma.

Lymphomas of different histologic type can occur in the same patient. Two types of lymphomas can be diagnosed in the same lymph node (composite lymphoma) or in different sites. In the latter case, terms as simultaneous and sequential have been proposed to define the detection of two lymphomas at the same time or at different times, respectively

The COMBS survey I : Chemical Origins of Metal-Poor Stars in the Galactic Bulge

19 pages, 5 tables, accepted to MNRASChemistry and kinematic studies can determine the origins of stellar population across the Milky Way. The metallicity distribution function of the bulge indicates that it comprises multiple populations, the more metal-poor end of which is particularly poorly understood. It is currently unknown if metal-poor bulge stars ([Fe/H] <−1 dex) are part of the stellar halo in the inner most region, or a distinct bulge population or a combination of these. Cosmological simulations also indicate that the metal-poor bulge stars may be the oldest stars in the Galaxy. In this study, we successfully target metal-poor bulge stars selected using SkyMapper photometry. We determine the stellar parameters of 26 stars and their elemental abundances for 22 elements using R∼ 47 000 VLT/UVES spectra and contrast their elemental properties with that of other Galactic stellar populations. We find that the elemental abundances we derive for our metal-poor bulge stars have lower overall scatter than typically found in the halo. This indicates that these stars may be a distinct population confined to the bulge. If these stars are, alternatively, part of the innermost distribution of the halo, this indicates that the halo is more chemically homogeneous at small Galactic radii than at large radii. We also find two stars whose chemistry is consistent with second-generation globular cluster stars. This paper is the first part of the Chemical Origins of Metal-poor Bulge Stars (COMBS) survey that will chemodynamically characterize the metal-poor bulge population.Peer reviewedFinal Published versio

Ruprecht 106: A riddle, wrapped in a mystery, inside an enigma

Galactic globular clusters (GCs) show overwhelming photometric and spectroscopic evidence for the existence of multiple stellar populations. The question of whether or not there exists a GC that represents a true 'simple stellar population' remains open. Here we focus on Ruprecht 106 (R106), a halo GC with [Fe/H]=-1.5 and [alpha/Fe]~0. A previous spectroscopic study found no sign of the Na-O anticorrelation among 9 of its brightest red giants, which led to the conclusion that R106 is a true simple stellar population GC. Here we present new Hubble Space Telescope (HST) Wide Field Camera 3 photometry of R106 that, when combined with archival HST images spanning a 6-year baseline, allows us to create proper motion cleaned color-magnitude diagrams spanning the ultraviolet (F336W) to the near-infrared (F814W). These data allow us to construct the pseudo-color C_{U,B,I} that is sensitive to the presence of light-element abundance spreads. We find no evidence of a split along the red giant branch (RGB) in the C_{U,B,I} diagram but the width of the RGB (sigma_CUBI = 0.015) is marginally broader than expected from artificial star tests (sigma_CUBI = 0.009). The observed spread in C_{U,B,I} is smaller than any other Galactic GC studied to date. Our results raise important questions about the role of formation environment and primordial chemical composition in the formation of multiple stellar populations in GCs.Comment: 11 pages, 5 figures, accepted versio

A single model for the variety of multiple-population formation(s) in globular clusters: A temporal sequence

We explain the multiple populations recently found in the ‘prototype’ globular cluster (GC) NGC 2808 in the framework of the asymptotic giant branch (AGB) scenario. The chemistry of the five – or more – populations is approximately consistent with a sequence of star formation events, starting after the Type II supernova epoch, lasting approximately until the time when the third dredge-up affects the AGB evolution (age ∼90–120 Myr), and ending when the Type Ia supernovae begin exploding in the cluster, eventually clearing it from the gas. The formation of the different populations requires episodes of star formation in AGB gas diluted with different amounts of pristine gas. In the nitrogen-rich, helium-normal population identified in NGC 2808 by the UV Legacy Survey of GCs, the nitrogen increase is due to the third dredge-up in the smallest mass AGB ejecta involved in the star formation of this population. The possibly iron-rich small population in NGC 2808 may be a result of contamination by a single Type Ia supernova. The NGC 2808 case is used to build a general framework to understand the variety of ‘second-generation’ stars observed in GCs. Cluster-to-cluster variations are ascribed to differences in the effects of the many processes and gas sources which may be involved in the formation of the second generation. We discuss an evolutionary scheme, based on pollution by delayed Type II supernovae, which accounts for the properties of s-Fe-anomalous clusters

Isolation and Characterization of Multiple Forms of Glutamate-Aspartate Aminotransferase from Pig Heart

Abstract At least four different protein fractions provided with aspartate aminotransferase activity can be isolated from pig heart cytoplasm. No difference is detected in the sedimentation coefficient, immunodiffusion properties, and primary structure (as studied by quantitative amino acid analysis and peptide mapping of tryptic digests) of the three main fractions, called, respectively, α, β, and γ in their order of increasing anodic mobility on starch gel electrophoresis. The three main fractions differ significantly in specific activity, kinetics of recombination of the apoenzyme with the coenzyme, and behavior in 8 m urea. The most visible difference among them is in the way in which the coenzyme is bound to the enzyme protein. In the α and β fractions, pyridoxal phosphate is bound mostly in an "active" mode, characterized by absorption peaks at 362 or 430 mµ (depending upon the pH) and by the capacity to transaminate reversibly with the amino acid substrates. In the γ form, most of the coenzyme is bound in a nonactive mode, characterized by an absorption peak at 340 mµ and by the incapacity to react with amino acid substrates. Upon aging, the α and β fractions lose some activity, while a portion of their coenzyme becomes bound in the inactive mode. Even after these changes have occurred, the various fractions maintain their electrophoretic individuality, which is also preserved after resolution and after treatment with concentrated urea. Electrophoretic analyses carried out on a water extract of a single heart taken immediately after the death of the animal reveal the presence of the various subforms; this indicates either that the various subforms exist as such in the living cell or, if they are artifacts, that they must be formed very early in the preparation and under extremely mild conditions